Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
نویسندگان
چکیده
منابع مشابه
Development of a minimal saponin vaccine adjuvant based on QS-21
Adjuvants are materials added to vaccines to enhance the immunological response to an antigen. QS-21 is a natural product adjuvant under investigation in numerous vaccine clinical trials, but its use is constrained by scarcity, toxicity, instability and an enigmatic molecular mechanism of action. Herein we describe the development of a minimal QS-21 analogue that decouples adjuvant activity fro...
متن کاملAtomic model and micelle dynamics of QS-21 saponin.
QS-21 is a saponin extracted from Quillaja saponaria, widely investigated as a vaccine immunoadjuvant. However, QS-21 use is mainly limited by its chemical instability, significant variety in molecular composition and low tolerance dose in mammals. Also, this compound tends to form micelles in a concentration-dependent manner. Here, we aimed to characterize its conformation and the process of m...
متن کاملQS-21: A Potent Vaccine Adjuvant.
Copyright: © 2015 Zhu D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. QS-21 is one of the active fractions of the bark of Chilean tree, Quillaja saponaria, purified using a reverse-phase chromatograp...
متن کاملDevelopment of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis
Vaccines based on molecular subunit antigens are increasingly being investigated due to their improved safety and more precise targeting compared to classical whole-pathogen vaccines. However, subunit vaccines are inherently less immunogenic; thus, coadministration of an adjuvant to increase the immunogenicity of the antigen is often necessary to elicit a potent immune response. QS-21, an immun...
متن کاملIdentification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.
Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules contribute to the stimulatory activity. QS-21 is a defined, highly purified, and soluble saponin adjuvant currently used in licensed and exploratory vaccines, including vaccines against malaria, cancer, and HIV-1. However, little is known about...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2011
ISSN: 1476-0584,1744-8395
DOI: 10.1586/erv.11.18